The effects of aerobic exercise on estrogen metabolism in healthy premenopausal women.

ABSTRACT:

Background

It is well accepted that exercise can decrease breast cancer risk. Limited clinical evidence suggests that this risk could be mediated through changes in estrogen metabolism in premenopausal women. Our objective was to investigate the effects of exercise on premenopausal estrogen metabolism pertinent to breast cancer risk.

Methods

Sedentary, healthy, young eumenorrheic women were randomized into an intervention of 30 minutes of moderate-to-vigorous aerobic exercise five times a week for approximately 16 weeks (n = 212), or into a usual-lifestyle sedentary control group (n = 179). Urinary levels of estrogens [estrone [E1], estradiol, and estriol] and nine estrogen metabolites were measured at baseline and at study end by liquid chromatography/tandem mass spectromet

SUBMITTER: Smith AJ 

PROVIDER: S-EPMC3648856 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature