Extended-release mixed amphetamine salts and topiramate for cocaine dependence: a randomized controlled trial.

ABSTRACT:

Background

Cocaine dependence is a substantial public health problem, yet there are no clearly effective medication treatments. Amphetamine and topiramate have both shown promise for the treatment of cocaine dependence in preclinical and early-stage clinical studies.

Methods

Eighty-one cocaine-dependent adults were randomized to receive a combination of extended-release mixed amphetamine salts (MAS-ER) and topiramate or placebo for 12 weeks under double-blind conditions. MAS-ER doses were titrated over 2 weeks to a maximum dose of 60 mg daily, and topiramate doses were titrated over 6 weeks to a maximum dose of 150 mg twice daily. All participants received a supportive behavioral intervention. The primary outcome was the proportion of individuals who achieved 3 consecutive w

SUBMITTER: Mariani JJ 

PROVIDER: S-EPMC3648884 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature