Translational Approaches towards Cancer Gene Therapy: Hurdles and Hopes.

ABSTRACT:

Introduction

Of the cancer gene therapy approaches, gene silencing, suicide/apoptosis inducing gene therapy, immunogene therapy and targeted gene therapy are deemed to sub-stantially control the biological consequences of genomic changes in cancerous cells. Thus, a large number of clinical trials have been conducted against various malignancies. In this review, we will discuss recent translational progresses of gene and cell therapy of cancer.

Methods

Essential information on gene therapy of cancer were reviewed and discussed towards their clinical translations.

Results

Gene transfer has been rigorously studied in vitro and in vivo, in which some of these gene therapy endeavours have been carried on towards translational investigations and clinical applications. About

SUBMITTER: Barar J 

PROVIDER: S-EPMC3648930 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature