Recruitment of EB1, a master regulator of microtubule dynamics, to the surface of the Theileria annulata schizont.

ABSTRACT: The apicomplexan parasite Theileria annulata transforms infected host cells, inducing uncontrolled proliferation and clonal expansion of the parasitized cell population. Shortly after sporozoite entry into the target cell, the surrounding host cell membrane is dissolved and an array of host cell microtubules (MTs) surrounds the parasite, which develops into the transforming schizont. The latter does not egress to invade and transform other cells. Instead, it remains tethered to host cell MTs and, during mitosis and cytokinesis, engages the cell's astral and central spindle MTs to secure its distribution between the two daughter cells. The molecular mechanism by which the schizont recruits and stabilizes host cell MTs is not known. MT minus ends are mostly anchored in the MT organizing cent

SUBMITTER: Woods KL 

PROVIDER: S-EPMC3649978 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature