Comparative proteomics analysis suggests that placental mitochondria are involved in the development of pre-eclampsia.

ABSTRACT:

Introduction

Pre-eclampsia (PE), a severe pregnancy-specific disease characterized by the new onset of hypertension, proteinuria, edema, and a series of other systematic disorders, is a state of widespread mitochondrial dysfunction of the placenta.

Methods

We compared the morphology of mitochondria in pre-eclamptic and normotensive placentae using electron microscopy. To reveal the systematic protein expression changes of placental mitochondria that might explain the pathogenesis of PE, we performed iTRAQ analysis combined with liquid chromatography-tandem mass spectrometry (LC-MS/MS) on differentially expressed placental mitochondria proteins from 4 normotensive and 4 pre-eclamptic pregnancies. Bioinformatics analysis was used to find the relative processes that these diffe

SUBMITTER: Shi Z 

PROVIDER: S-EPMC3650054 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature