Risk assessment of upper tract urothelial carcinoma related to aristolochic acid.

ABSTRACT:

Background

Aristolochic acid is a toxin found in plants of the genus Aristolochia, to which humans can be exposed either through certain Chinese herbal medicines or through inadvertent commingling with food crops. Our objective was to estimate cumulative exposures of aristolochic acid associated with increased risk of end-stage renal disease (ESRD), and to conduct a systematic review and meta-analysis on aristolochic acid-induced upper tract urothelial carcinoma (UUC).

Methods

Using epidemiologic studies on aristolochic acid-related disease from multiple different regions of the world, a systematic review was conducted in which relative risks (RR), HRs, and ORs were derived or extracted directly, and a meta-analysis was conducted. One study was used to estimate a benchmark d

SUBMITTER: Wu F 

PROVIDER: S-EPMC3650093 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature