Relationship of adiposity to bone volumetric density and microstructure in men and women across the adult lifespan.

ABSTRACT: Recent evidence suggests that adipose tissue may negatively impact bone health, challenging the traditional paradigm that increased fat mass, through mechanical loading or endogenous estrogen production, is beneficial to the skeleton. We hypothesized that it is primarily the visceral compartment of body fat that is detrimental to bone metabolism, resulting in impaired bone density and architecture. In an age-stratified population sample of 218 women and 291 men (age 20-97 years), we assessed visceral (VAT) and subcutaneous (SAT) adipose tissue areas at the L2-L3 interspace level by single slice quantitative computed tomography (QCT) and measured total body fat mass (TBF) by dual-energy X-ray absorptiometry. We then correlated these findings with volumetric bone mineral density (vBMD) at th

SUBMITTER: Ng AC 

PROVIDER: S-EPMC3650114 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature