Gas-phase fragmentation of oligoproline peptide ions lacking easily mobilizable protons.
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ABSTRACT:
SUBMITTER: Rudowska M
PROVIDER: S-EPMC3650240 | biostudies-literature | 2013 Jun
REPOSITORIES: biostudies-literature
Publications
Gas-phase fragmentation of oligoproline peptide ions lacking easily mobilizable protons.
Rudowska Magdalena M Wieczorek Robert R Kluczyk Alicja A Stefanowicz Piotr P Szewczuk Zbigniew Z
Journal of the American Society for Mass Spectrometry 20130423 6
The fragmentation of peptides containing quaternary ammonium group, but lacking easily mobilizable protons, was examined with the aid of deuterium-labeled analogs and quantum-chemical modeling. The fragmentation of oligoproline containing quaternary ammonium group involves the mobilization of hydrogens localized at α- and γ- or δ-carbon atoms in the pyrrolidine ring of proline. The study of the dissociation pattern highlights the unusual proline residue behavior during MS/MS experiments of pepti ...[more]
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