Conserved Non-Coding Sequences are Associated with Rates of mRNA Decay in Arabidopsis.

ABSTRACT: Steady-state mRNA levels are tightly regulated through a combination of transcriptional and post-transcriptional control mechanisms. The discovery of cis-acting DNA elements that encode these control mechanisms is of high importance. We have investigated the influence of conserved non-coding sequences (CNSs), DNA patterns retained after an ancient whole genome duplication event, on the breadth of gene expression and the rates of mRNA decay in Arabidopsis thaliana. The absence of CNSs near α duplicate genes was associated with a decrease in breadth of gene expression and slower mRNA decay rates while the presence CNSs near α duplicates was associated with an increase in breadth of gene expression and faster mRNA decay rates. The observed difference in mRNA decay rate was fastest in genes wi

SUBMITTER: Spangler JB 

PROVIDER: S-EPMC3650315 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature