Multispecificity of immunoglobulin M antibodies raised against advanced glycation end products: involvement of electronegative potential of antigens.

ABSTRACT:

Background

Advanced glycation end products (AGEs) can act as neoantigens to trigger immune responses.

Results

Natural IgM antibodies against AGEs recognize multiple molecules, including DNA and chemically modified proteins.

Conclusion

There is a close relationship between the formation of AGEs and innate immune responses.

Significance

Our findings highlight AGEs and related modified proteins as a source of multispecific natural antibodies Advanced glycation end products (AGEs) are a heterogeneous and complex group of compounds that are formed when reducing sugars, such as dehydroascorbic acid, react in a nonenzymatic way with amino acids in proteins and other macromolecules. AGEs are prevalent in the diabetic vasculature and contribute to the development of ath

SUBMITTER: Chikazawa M 

PROVIDER: S-EPMC3650360 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature