The signal peptide of the tumor-shared antigen midkine hosts CD4+ T cell epitopes.

ABSTRACT:

Background

The CD4 T cell response to the tumor antigen Midkine was unknown.

Results

Most of the T cell response to Midkine relies on T cell epitopes contained in its signal peptide.

Conclusion

The signal peptide of Midkine is accessible to HLA class II pathway for CD4 T cell presentation.

Significance

It is a new function for signal peptides to contribute to tumor-specific CD4 T cell response. Because of the key role of CD4 T cell response in immunity to tumors, we investigated the CD4(+) T cell response to the recently identified tumor antigen Midkine (MDK). By weekly stimulations of T lymphocytes harvested from seven HLA-DR-typed healthy donors, we derived CD4(+) T cell lines specific for eight MDK peptides. Most of the T cell lines reacted with the peptides

SUBMITTER: Kerzerho J 

PROVIDER: S-EPMC3650375 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature