Structure and activity of the flagellar rotor protein FliY: a member of the CheC phosphatase family.

ABSTRACT:

Background

FliY is a flagellar rotor protein of the CheC phosphatase family.

Results

The FliY structure resembles that of the rotor protein FliM but contains two active centers for CheY dephosphorylation.

Conclusion

FliY incorporates properties of the FliM/FliN rotor proteins and the CheC/CheX phosphatases to serve multiple functions in the flagellar switch.

Significance

FliY distinguishes flagellar architecture and function in different types of bacteria. Rotating flagella propel bacteria toward favorable environments. Sense of rotation is determined by the intracellular response regulator CheY, which when phosphorylated (CheY-P) interacts directly with the flagellar motor. In many different types of bacteria, the CheC/CheX/FliY (CXY) family of phosphatases te

SUBMITTER: Sircar R 

PROVIDER: S-EPMC3650386 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature