A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump: multimers of phospholemman in ventricular muscle.

ABSTRACT:

Background

Phospholemman regulates the plasmalemmal sodium pump in excitable tissues.

Results

In cardiac muscle, a subpopulation of phospholemman with a unique phosphorylation signature associates with other phospholemman molecules but not with the pump.

Conclusion

Phospholemman oligomers exist in cardiac muscle.

Significance

Much like phospholamban regulation of SERCA, phospholemman exists as both a sodium pump inhibiting monomer and an unassociated oligomer. Phospholemman (PLM), the principal quantitative sarcolemmal substrate for protein kinases A and C in the heart, regulates the cardiac sodium pump. Much like phospholamban, which regulates the related ATPase SERCA, PLM is reported to oligomerize. We investigated subpopulations of PLM in adult rat ventricul

SUBMITTER: Wypijewski KJ 

PROVIDER: S-EPMC3650417 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature