The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation.

ABSTRACT: Bile acids (BAs) are amphipathic molecules that facilitate the uptake of lipids, and their levels fluctuate in the intestine as well as in the blood circulation depending on food intake. Besides their role in dietary lipid absorption, bile acids function as signaling molecules capable to activate specific receptors. These BA receptors are not only important in the regulation of bile acid synthesis and their metabolism, but also regulate glucose homeostasis, lipid metabolism, and energy expenditure. These processes are important in diabetes and other facets of the metabolic syndrome, which represents a considerable increasing health burden. In addition to the function of the nuclear receptor FXRα in regulating local effects in the organs of the enterohepatic axis, increasing evidence points

SUBMITTER: Pols TW 

PROVIDER: S-EPMC3650458 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature