Cloning and analysis of the planosporicin lantibiotic biosynthetic gene cluster of Planomonospora alba.

ABSTRACT: The increasing prevalence of antibiotic resistance in bacterial pathogens has renewed focus on natural products with antimicrobial properties. Lantibiotics are ribosomally synthesized peptide antibiotics that are posttranslationally modified to introduce (methyl)lanthionine bridges. Actinomycetes are renowned for their ability to produce a large variety of antibiotics, many with clinical applications, but are known to make only a few lantibiotics. One such compound is planosporicin produced by Planomonospora alba, which inhibits cell wall biosynthesis in Gram-positive pathogens. Planosporicin is a type AI lantibiotic structurally similar to those which bind lipid II, the immediate precursor for cell wall biosynthesis. The gene cluster responsible for planosporicin biosynthesis was identifi

SUBMITTER: Sherwood EJ 

PROVIDER: S-EPMC3650528 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature