Efficient EGFR signaling and dorsal-ventral axis patterning requires syntaxin dependent Gurken trafficking.

ABSTRACT: Vesicle trafficking plays a crucial role in the establishment of cell polarity in various cellular contexts, including axis-pattern formation in the developing egg chamber of Drosophila. The EGFR ligand, Gurken (Grk), is first localized at the posterior of young oocytes for anterior-posterior axis formation and later in the dorsal anterior region for induction of the dorsal-ventral (DV) axis, but regulation of Grk localization by membrane trafficking in the oocyte remains poorly understood. Here, we report that Syntaxin 1A (Syx1A) is required for efficient trafficking of Grk protein for DV patterning. We show that Syx1A is associated with the Golgi membrane and is required for the transportation of Grk-containing vesicles along the microtubules to their dorsal anterior destination in the o

SUBMITTER: Tian AG 

PROVIDER: S-EPMC3650911 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature