Genetic variation in TLR or NFkappaB pathways and the risk of breast cancer: a case-control study.

ABSTRACT:

Background

Toll-like receptors (TLRs) and the transcription factor nuclear factor-κB (NFκB) are important in inflammation and cancer.

Methods

We examined the association between breast cancer risk and 233 tagging single nucleotide polymorphisms within 31 candidate genes involved in TLR or NFκB pathways. This population-based study in the Seattle area included 845 invasive breast cancer cases, diagnosed between 1997 and 1999, and 807 controls aged 65-79.

Results

Variant alleles in four genes were associated with breast cancer risk based on gene-level tests: MAP3K1, MMP9, TANK, and TLR9. These results were similar when the risk of breast cancer was examined within ductal and luminal subtypes. Subsequent exploratory pathway analyses using the GRASS algorithm found no ass

SUBMITTER: Resler AJ 

PROVIDER: S-EPMC3651307 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature