Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors.

ABSTRACT:

Purpose

Germ cell tumor (GCT) is the most common malignancy in young adult men. Currently, patients are risk-stratified on the basis of clinical presentation and serum tumor markers. The introduction of molecular markers could improve outcome prediction.

Patients and methods

Expression profiling was performed on 74 nonseminomatous GCTs (NSGCTs) from cisplatin-treated patients (ie, training set) and on 34 similarly treated patients with NSGCTs (ie, validation set). A gene classifier was developed by using prediction analysis for microarrays (PAM) for the binary end point of 5-year overall survival (OS). A predictive score was developed for OS by using the univariate Cox model.

Results

In the training set, PAM identified 140 genes that predicted 5-year OS (cross-validat

SUBMITTER: Korkola JE 

PROVIDER: S-EPMC3651602 | biostudies-literature | 2009 Nov

REPOSITORIES: biostudies-literature