TI-CE high-dose chemotherapy for patients with previously treated germ cell tumors: results and prognostic factor analysis.

ABSTRACT:

Purpose

We previously reported a dose-finding and phase II trial of the TI-CE regimen (paclitaxel [T] plus ifosfamide [I] followed by high-dose carboplatin [C] plus etoposide [E] with stem-cell support) in germ cell tumor (GCT) patients predicted to have a poor prognosis with conventional-dose salvage therapy. We now report the efficacy of TI-CE with prognostic factors for disease-free survival (DFS) and overall survival (OS) in our full data set of 107 patients.

Patients and methods

Eligible patients had advanced GCTs with progressive disease following chemotherapy and unfavorable prognostic features (extragonadal primary site, incomplete response [IR] to first-line therapy, or relapse/IR to ifosfamide-cisplatin-based conventional-dose salvage). Univariate and multivariate

SUBMITTER: Feldman DR 

PROVIDER: S-EPMC3651604 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature