Stem cell therapy for cardiovascular disease: the demise of alchemy and rise of pharmacology.

ABSTRACT: Regenerative medicine holds great promise as a way of addressing the limitations of current treatments of ischaemic disease. In preclinical models, transplantation of different types of stem cells or progenitor cells results in improved recovery from ischaemia. Furthermore, experimental studies indicate that cell therapy influences a spectrum of processes, including neovascularization and cardiomyogenesis as well as inflammation, apoptosis and interstitial fibrosis. Thus, distinct strategies might be required for specific regenerative needs. Nonetheless, clinical studies have so far investigated a relatively small number of options, focusing mainly on the use of bone marrow-derived cells. Rapid clinical translation resulted in a number of small clinical trials that do not have sufficient p

SUBMITTER: Jadczyk T 

PROVIDER: S-EPMC3651654 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature