Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance.

ABSTRACT:

Aims/hypothesis

Insulin clearance is a highly heritable trait, for which few quantitative trait loci have been discovered. We sought to determine whether validated type 2 diabetes and/or glycaemic trait loci are associated with insulin clearance.

Methods

Hyperinsulinaemic-euglycaemic clamps were performed in two Hispanic-American family cohorts totalling 1329 participants in 329 families. The Metabochip was used to fine-map about 50 previously identified loci for type 2 diabetes, fasting glucose, fasting insulin, 2 h glucose or HbA1c. This resulted in 17,930 variants, which were tested for association with clamp-derived insulin clearance via meta-analysis of the two cohorts.

Results

In the meta-analysis, 38 variants located within seven loci demonstrated association w

SUBMITTER: Goodarzi MO 

PROVIDER: S-EPMC3651757 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature