The case of drug causation of childhood asthma: antibiotics and paracetamol.

ABSTRACT:

Aim

The rising prevalence of bronchial asthma has led to world-wide efforts to understand and stem this development. Cross-sectional studies appear to show that early childhood use of antibiotics may be an important contributory factor, with paracetamol as an additional suspected cause. However, mounting evidence, which is reviewed here, points to various confounding factors as the major reasons for these reported associations.

Methods

PubMed and EMBASE were systematically searched for studies on associations between antibiotics and/or paracetamol with asthma and/or wheezing, published up to November 2012. A total of 64 pertinent studies were identified, 35 focusing on antibiotics, 19 on paracetamol, and ten addressing both antibiotics and paracetamol, bringing the number of

SUBMITTER: Heintze K 

PROVIDER: S-EPMC3651816 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature