Genetic variation in the transforming growth factor-β-signaling pathway, lifestyle factors, and risk of colon or rectal cancer.

ABSTRACT:

Background

The transforming growth factor-β-signaling pathway has been identified as being involved in colorectal cancer.

Objective

The aim of this study was to determine how diet and lifestyle factors in combination with genetic variation in the transforming growth factor-β-signaling pathway alters colorectal cancer risk.

Design

We used data from 2 population-based case-control studies.

Patients

Participants included patients with colon cancer (n = 1574) and controls (n = 1970) and patients with rectal cancer ( n = 791) and controls (n = 999).

Main outcome measures

The primary outcomes measured were newly diagnosed cases of colon or rectal cancer.

Results

Colon and rectal cancer risk increased with the number of at-risk genotypes within the trans

SUBMITTER: Slattery ML 

PROVIDER: S-EPMC3652588 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature