NFKBIA deletion in glioblastomas.

ABSTRACT:

Background

Amplification and activating mutations of the epidermal growth factor receptor (EGFR) oncogene are molecular hallmarks of glioblastomas. We hypothesized that deletion of NFKBIA (encoding nuclear factor of κ-light polypeptide gene enhancer in B-cells inhibitor-α), an inhibitor of the EGFR-signaling pathway, promotes tumorigenesis in glioblastomas that do not have alterations of EGFR.

Methods

We analyzed 790 human glioblastomas for deletions, mutations, or expression of NFKBIA and EGFR. We studied the tumor-suppressor activity of NFKBIA in tumor-cell culture. We compared the molecular results with the outcome of glioblastoma in 570 affected persons.

Results

NFKBIA is often deleted but not mutated in glioblastomas; most deletions occur in nonclassical subtypes

SUBMITTER: Bredel M 

PROVIDER: S-EPMC3652611 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature