Higher postprandial serum ghrelin among African-American girls before puberty.

ABSTRACT:

Objective

Recent reports suggest that ghrelin regulation may differ by ethnicity and age. This study was designed to examine circulating ghrelin among overweight female African Americans across different age groups.

Methods

Eleven overweight peripubertal girls, 17 overweight pubertal girls, and a control group of 18 overweight African-American premenopausal women ingested a standard liquid meal after an overnight fast. Blood samples were obtained before the meal and for 4 h postchallenge. Participants rated appetite by a visual analog scale.

Results

Peripubertal girls demonstrated higher postprandial ghrelin and lesser ghrelin suppression compared with adults (p < 0.05), corresponding with greater desire to eat across the test period (p = 0.017). Fasting ghrelin tende

SUBMITTER: Ellis AC 

PROVIDER: S-EPMC3652648 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature