Radial glial cells play a key role in echinoderm neural regeneration.

ABSTRACT:

Background

Unlike the mammalian central nervous system (CNS), the CNS of echinoderms is capable of fast and efficient regeneration following injury and constitutes one of the most promising model systems that can provide important insights into evolution of the cellular and molecular events involved in neural repair in deuterostomes. So far, the cellular mechanisms of neural regeneration in echinoderm remained obscure. In this study we show that radial glial cells are the main source of new cells in the regenerating radial nerve cord in these animals.

Results

We demonstrate that radial glial cells of the sea cucumber Holothuria glaberrima react to injury by dedifferentiation. Both glia and neurons undergo programmed cell death in the lesioned CNS, but it is the dedifferentia

SUBMITTER: Mashanov VS 

PROVIDER: S-EPMC3652774 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature