Calcium-deficiency assessment and biomarker identification by an integrated urinary metabonomics analysis.

ABSTRACT:

Background

Calcium deficiency is a global public-health problem. Although the initial stage of calcium deficiency can lead to metabolic alterations or potential pathological changes, calcium deficiency is difficult to diagnose accurately. Moreover, the details of the molecular mechanism of calcium deficiency remain somewhat elusive. To accurately assess and provide appropriate nutritional intervention, we carried out a global analysis of metabolic alterations in response to calcium deficiency.

Methods

The metabolic alterations associated with calcium deficiency were first investigated in a rat model, using urinary metabonomics based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and multivariate statistical analysis

SUBMITTER: Wang M 

PROVIDER: S-EPMC3652781 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature