Genetic variants of MARCO are associated with susceptibility to pulmonary tuberculosis in a Gambian population.

ABSTRACT:

Background

The two major class A scavenger receptors are scavenger receptor A (SRA), which is constitutively expressed on most macrophage populations, and macrophage receptor with collagenous structure (MARCO), which is constitutively expressed on a more restricted subset of macrophages, (e.g. alveolar macrophages) but whose expression increases on most macrophages during the course of infection. Although the primary role of SRA appears to be clearance of modified host proteins and lipids, mice defective in expression of either MARCO or SRA are immunocompromised in multiple models of infection and in vitro assays, the scavenger receptors have been demonstrated to bind bacteria and to enhance pro-inflammatory signalling to many bacterial lung pathogens; however their importance in M

SUBMITTER: Bowdish DM 

PROVIDER: S-EPMC3652798 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature