Efficacy of mitomycin C in endoscopic dacryocystorhinostomy: a systematic review and meta-analysis.

ABSTRACT:

Background

A number of published comparative studies have been conducted to evaluate the efficacy and safety of intraoperative mitomycin C (MMC) in endoscopic dacryocystorhinostomy (EN-DCR). However, results have not always been consistent. Therefore, we carried out a meta-analysis to compare the clinical results of EN-DCR with and without MMC.

Methods and findings

A comprehensive literature search of Cochrane Library, PubMed and EMBASE to identify relevant trials comparing EN-DCR with and without MMC. Eleven studies including 574 eyes were included in this meta-analysis. The success was defined as patency of the nasolacrimal canal and symptomatic improvement. There was significantly higher success rate in the MMC group in comparison with control group [RR = 1.12, 95% CI (1.

SUBMITTER: Cheng SM 

PROVIDER: S-EPMC3652813 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature