A cocoa peptide protects Caenorhabditis elegans from oxidative stress and β-amyloid peptide toxicity.

ABSTRACT:

Background

Cocoa and cocoa-based products contain different compounds with beneficial properties for human health. Polyphenols are the most frequently studied, and display antioxidant properties. Moreover, protein content is a very interesting source of antioxidant bioactive peptides, which can be used therapeutically for the prevention of age-related diseases.

Methodology/principal findings

A bioactive peptide, 13L (DNYDNSAGKWWVT), was obtained from a hydrolyzed cocoa by-product by chromatography. The in vitro inhibition of prolyl endopeptidase (PEP) was used as screening method to select the suitable fraction for peptide identification. Functional analysis of 13L peptide was achieved using the transgenic Caenorhabditis elegans strain CL4176 expressing the human Aβ₁₋₄₂ pept

SUBMITTER: Martorell P 

PROVIDER: S-EPMC3652819 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature