Integrating murine gene expression studies to understand obstructive lung disease due to chronic inhaled endotoxin.

ABSTRACT:

Rationale

Endotoxin is a near ubiquitous environmental exposure that that has been associated with both asthma and chronic obstructive pulmonary disease (COPD). These obstructive lung diseases have a complex pathophysiology, making them difficult to study comprehensively in the context of endotoxin. Genome-wide gene expression studies have been used to identify a molecular snapshot of the response to environmental exposures. Identification of differentially expressed genes shared across all published murine models of chronic inhaled endotoxin will provide insight into the biology underlying endotoxin-associated lung disease.

Methods

We identified three published murine models with gene expression profiling after repeated low-dose inhaled endotoxin. All array data from these

SUBMITTER: Lai PS 

PROVIDER: S-EPMC3652821 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature