New insights into FoxE1 functions: identification of direct FoxE1 targets in thyroid cells.

ABSTRACT:

Background

FoxE1 is a thyroid-specific forkhead transcription factor essential for thyroid gland development, as well as for the maintenance of the thyroid differentiated state in adults. FoxE1 recognizes and binds to a short DNA sequence present in thyroglobulin (Tg) and thyroperoxidase (Tpo) promoters, but FoxE1 binding to regulatory regions other than Tg and Tpo promoters remains almost unexplored. Improving knowledge of the regulatory functions of FoxE1 is necessary to clarify its role in endocrine syndromes and cancer susceptibility.

Methodology/principal finding

In order to further investigate downstream FoxE1 targets, we performed a genome-wide expression screening after knocking-down FoxE1 and obtained new insights into FoxE1 transcriptional networks in thyroid folli

SUBMITTER: Fernandez LP 

PROVIDER: S-EPMC3652843 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature