Weight change at 1 mo of antiretroviral therapy and its association with subsequent mortality, morbidity, and CD4 T cell reconstitution in a Tanzanian HIV-infected adult cohort.

ABSTRACT:

Background

The development of low-cost point-of-care technologies to improve HIV treatment is a major focus of current research in resource-limited settings.

Objective

We assessed associations of body mass index (BMI; in kg/m(2)) at antiretroviral therapy (ART) initiation and weight change after 1 mo of treatment with mortality, morbidity, and CD4 T cell reconstitution.

Design

A prospective cohort of 3389 Tanzanian adults initiating ART enrolled in a multivitamin trial was followed at monthly clinic visits (median: 19.7 mo). Proportional hazard models were used to analyze mortality and morbidity associations, whereas generalized estimating equations were used for CD4 T cell counts.

Results

The median weight change at 1 mo of ART was +2.0% (IQR: -0.4% to +4.6%).

SUBMITTER: Sudfeld CR 

PROVIDER: S-EPMC3652924 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature