Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.

ABSTRACT:

Background

Macronutrient intake varies substantially between individuals, and there is evidence that this variation is partly accounted for by genetic variants.

Objective

The objective of the study was to identify common genetic variants that are associated with macronutrient intake.

Design

We performed 2-stage genome-wide association (GWA) meta-analysis of macronutrient intake in populations of European descent. Macronutrients were assessed by using food-frequency questionnaires and analyzed as percentages of total energy consumption from total fat, protein, and carbohydrate. From the discovery GWA (n = 38,360), 35 independent loci associated with macronutrient intake at P < 5 × 10(-6) were identified and taken forward to replication in 3 additional cohorts (n = 33,5

SUBMITTER: Tanaka T 

PROVIDER: S-EPMC3652928 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature