Usefulness of applying lidocaine in esophagogastroduodenoscopy performed under sedation with propofol.

ABSTRACT:

Aim

To determine whether topical lidocaine benefits esophagogastroduoduenoscopy (EGD) by decreasing propofol dose necessary for sedation or procedure-related complications.

Methods

The study was designed as a prospective, single centre, double blind, randomised clinical trial and was conducted in 2012 between January and May (NCT01489891). Consecutive patients undergoing EGD were randomly assigned to receive supplemental topical lidocaine (L; 50 mg in an excipient solution which was applied as a spray to the oropharynx) or placebo (P; taste excipients solution without active substance, similarly delivered) prior to the standard propofol sedation procedure. The propofol was administered as a bolus intravenous (iv) dose, with patients in the L and P groups receiving initial do

SUBMITTER: de la Morena F 

PROVIDER: S-EPMC3653022 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature