Three new single nucleotide polymorphisms identified by a genome-wide association study in Korean patients with vitiligo.

ABSTRACT: Genetic susceptibility is involved in the pathogenesis of vitiligo. Association studies with a whole genome-based approach instead of a single or a few candidate genes may be useful for discovering new susceptible genes. Although the etiology of non-segmental and segmental types is different, the association between gene polymorphisms and vitiligo has been reported, without defining types or in non-segmental type. Whole genome-based single nucleotide polymorphisms (SNPs) were examined in patients with non-segmental and segmental types of vitiligo using the Affymetrix GeneChip 500K mapping array, and 10 functional classes of significant SNPs were selected. Genotyping and data analysis of selected 10 SNPs was performed using real-time PCR. Genotype and allele frequencies were significantly d

SUBMITTER: Cheong KA 

PROVIDER: S-EPMC3653093 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature