Shared loci for migraine and epilepsy on chromosomes 14q12-q23 and 12q24.2-q24.3.

ABSTRACT:

Objectives

To describe clinical characteristics and to identify susceptibility loci for epilepsy and migraine in a Finnish family with a complex phenotype.

Methods

Participating family members were interviewed and medical files were reviewed. The seizure classification was made according to International League Against Epilepsy criteria. Migraine diagnosis was made using the validated Finnish Migraine Specific Questionnaire for Family Studies and criteria according to the current International Classification of Headache Disorders-II. DNA samples were obtained from 56 family members and nonparametric genome-wide linkage analyses were performed using 382 polymorphic microsatellite markers. The most promising loci were fine-mapped with additional microsatellite markers.

Resu

SUBMITTER: Polvi A 

PROVIDER: S-EPMC3653199 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature