Elevation of proinflammatory cytokines in patients with Aicardi-Goutieres syndrome.

ABSTRACT:

Objective

This study explores a large panel of cytokines in plasma and CSF of patients with Aicardi-Goutières syndrome (AGS) at different ages, in order to establish signatures of cytokines most predictive of AGS.

Methods

Plasma from 22 subjects with known mutations were assayed for cytokines using the Milliplex MAP Immunobead system, and compared to results from 8 age-matched normal controls. CSF of 11 additional patients with mutation-proven AGS was tested in an identical manner and compared to results from age-matched controls. Samples were banked and analysis was carried out retrospectively.

Results

Significant elevations were seen in FMS-related tyrosine kinase 3 ligand, IP-10, interleukin (IL)-12p40, IL-15, tumor necrosis factor α, and soluble IL 2 receptor α in

SUBMITTER: Takanohashi A 

PROVIDER: S-EPMC3653200 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature