Thrombogenic microvesicles and white matter hyperintensities in postmenopausal women.

ABSTRACT:

Objective

To determine the association of conventional cardiovascular risk factors, markers of platelet activation, and thrombogenic blood-borne microvesicles with white matter hyperintensity (WMH) load and progression in recently menopausal women.

Methods

Women (n = 95) enrolled in the Mayo Clinic Kronos Early Estrogen Prevention Study underwent MRI at baseline and at 18, 36, and 48 months after randomization to hormone treatments. Conventional cardiovascular risk factors, carotid intima-medial thickness, coronary arterial calcification, plasma lipids, markers of platelet activation, and thrombogenic microvesicles were measured at baseline. WMH volumes were calculated using a semiautomated segmentation algorithm based on fluid-attenuated inversion recovery MRI. Correlations

SUBMITTER: Raz L 

PROVIDER: S-EPMC3653211 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature