Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study.

ABSTRACT:

Objective

To assess safety and efficacy of an oral, single, low dose of octanoic acid (OA) in subjects with alcohol-responsive essential tremor (ET).

Methods

We conducted a double-blind, placebo-controlled, crossover, phase I/II clinical trial evaluating the effect of 4 mg/kg OA in 19 subjects with ET. The primary outcome was accelerometric postural tremor power of the dominant hand 80 minutes after administration. Secondary outcomes included digital spiral analysis, pharmacokinetic sampling, as well as safety measures.

Results

OA was safe and well tolerated. Nonserious adverse events were mild (Common Terminology Criteria for Adverse Events grade 1) and equally present after OA and placebo. At the primary outcome, OA effects were not different from placebo. Secondary

SUBMITTER: Haubenberger D 

PROVIDER: S-EPMC3653213 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature