Association between the chromosome 9p21 locus and angiographic coronary artery disease burden: a collaborative meta-analysis.

ABSTRACT:

Objectives

This study sought to ascertain the relationship of 9p21 locus with: 1) angiographic coronary artery disease (CAD) burden; and 2) myocardial infarction (MI) in individuals with underlying CAD.

Background

Chromosome 9p21 variants have been robustly associated with coronary heart disease, but questions remain on the mechanism of risk, specifically whether the locus contributes to coronary atheroma burden or plaque instability.

Methods

We established a collaboration of 21 studies consisting of 33,673 subjects with information on both CAD (clinical or angiographic) and MI status along with 9p21 genotype. Tabular data are provided for each cohort on the presence and burden of angiographic CAD, MI cases with underlying CAD, and the diabetic status of all subjects.

SUBMITTER: Chan K 

PROVIDER: S-EPMC3653306 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature