Dynamic bonds and polar ejection force distribution explain kinetochore oscillations in PtK1 cells.

ABSTRACT: Duplicated mitotic chromosomes aligned at the metaphase plate maintain dynamic attachments to spindle microtubules via their kinetochores, and multiple motor and nonmotor proteins cooperate to regulate their behavior. Depending on the system, sister chromatids may display either of two distinct behaviors, namely (1) the presence or (2) the absence of oscillations about the metaphase plate. Significantly, in PtK1 cells, in which chromosome behavior appears to be dependent on the position along the metaphase plate, both types of behavior are observed within the same spindle, but how and why these distinct behaviors are manifested is unclear. Here, we developed a new quantitative model to describe metaphase chromosome dynamics via kinetochore-microtubule interactions mediated by nonmotor visc

SUBMITTER: Civelekoglu-Scholey G 

PROVIDER: S-EPMC3653364 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature