Investigating highly replicated asthma genes as candidate genes for allergic rhinitis.

ABSTRACT:

Background

Asthma genetics has been extensively studied and many genes have been associated with the development or severity of this disease. In contrast, the genetic basis of allergic rhinitis (AR) has not been evaluated as extensively. It is well known that asthma is closely related with AR since a large proportion of individuals with asthma also present symptoms of AR, and patients with AR have a 5-6 fold increased risk of developing asthma. Thus, the relevance of asthma candidate genes as predisposing factors for AR is worth investigating. The present study was designed to investigate if SNPs in highly replicated asthma genes are associated with the occurrence of AR.

Methods

A total of 192 SNPs from 21 asthma candidate genes reported to be associated with asthma in 6 or

SUBMITTER: Andiappan AK 

PROVIDER: S-EPMC3653682 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature