Palettes of vaccines and immunostimulatory monoclonal antibodies for combination.

ABSTRACT: Various monoclonal antibodies (mAb) target immune system molecules to enhance immunity by costimulating T cells (i.e., CD137, OX40, CD40, GITR) or interfering in coinhibitory signals (i.e., CTLA-4, PD-1). These powerful agents can be guided by cancer vaccines to enhance immunity against tumor but not self tissues. Clinically powerful therapeutic synergies are at hand.

SUBMITTER: Melero I 

PROVIDER: S-EPMC3653776 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature