Interactions between the FTO and GNB3 genes contribute to varied clinical phenotypes in hypertension.

ABSTRACT:

Background

The genes FTO and GNB3 are implicated in essential hypertension but their interaction remains to be explored. This study investigates the role of interaction between the two genes in the pathophysiology of essential hypertension.

Methods/principal findings

In a case-control study comprising 750 controls and 550 patients, interaction between the polymorphisms of FTO and GNB3 was examined using multifactor dimensionality reduction (MDR). The influence of interaction on clinical phenotypes like systolic and diastolic blood pressure, mean arterial pressure and body mass index was also investigated. The 3-locus MDR model comprising FTO rs8050136C/A and GNB3 rs1129649T/C and rs5443C/T emerged as the best disease conferring model. Moreover, the interacted-genotypes havin

SUBMITTER: Kumar R 

PROVIDER: S-EPMC3653800 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature