A multigene expression assay to predict local recurrence risk for ductal carcinoma in situ of the breast.

ABSTRACT:

Background

For women with ductal carcinoma in situ (DCIS) of the breast, the risk of developing an ipsilateral breast event (IBE; defined as local recurrence of DCIS or invasive carcinoma) after surgical excision without radiation is not well defined by clinical and pathologic characteristics.

Methods

The Oncotype DX breast cancer assay was performed for patients with DCIS treated with surgical excision without radiation in the Eastern Cooperative Oncology Group (ECOG) E5194 study. The association of the prospectively defined DCIS Score (calculated from seven cancer-related genes and five reference genes) with the risk of developing an IBE was analyzed using Cox regression. All statistical tests were two-sided.

Results

There were 327 patients with adequate tissue for

SUBMITTER: Solin LJ 

PROVIDER: S-EPMC3653823 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature