Predicted plasma 25-hydroxyvitamin D and risk of renal cell cancer.

ABSTRACT:

Background

Although the kidney is a primary organ for vitamin D metabolism, the association between vitamin D and renal cell cancer (RCC) remains unclear.

Methods

We prospectively evaluated the association between predicted plasma 25-hydroxyvitamin D [25(OH)D] and RCC risk among 72,051 women and 46,380 men in the period from 1986 to 2008. Predicted plasma 25(OH)D scores were computed using validated regression models that included major determinants of vitamin D status (race, ultraviolet B flux, physical activity, body mass index, estimated vitamin D intake, alcohol consumption, and postmenopausal hormone use in women). Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards models. All statistical tests were two-sided.

Result

SUBMITTER: Joh HK 

PROVIDER: S-EPMC3653824 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature