Ontology highlight
ABSTRACT:
SUBMITTER: Harazono Y
PROVIDER: S-EPMC3653886 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Harazono Yosuke Y Muramatsu Tomoki T Endo Hironori H Uzawa Narikazu N Kawano Tatsuyuki T Harada Kiyoshi K Inazawa Johji J Kozaki Ken-ichi K
PloS one 20130514 5
Recently, the epithelial-to-mesenchymal transition (EMT) has been demonstrated to contribute to normal and disease processes including cancer progression. To explore EMT-suppressive microRNAs (miRNAs), we established a cell-based reporter system using a stable clone derived from a pancreatic cancer cell line, Panc1, transfected with a reporter construct containing a promoter sequence of CDH1/E-cadherin in the 5' upstream region of the ZsGreen1 reporter gene. Then, we performed function-based scr ...[more]