Relating the bipolar spectrum to dysregulation of behavioural activation: a perspective from dynamical modelling.

ABSTRACT: Bipolar Disorders affect a substantial minority of the population and result in significant personal, social and economic costs. Understanding of the causes of, and consequently the most effective interventions for, this condition is an area requiring development. Drawing upon theories of Bipolar Disorder that propose the condition to be underpinned by dysregulation of systems governing behavioural activation or approach motivation, we present a mathematical model of the regulation of behavioural activation. The model is informed by non-linear, dynamical principles and as such proposes that the transition from "non-bipolar" to "bipolar" diagnostic status corresponds to a switch from mono- to multistability of behavioural activation level, rather than an increase in oscillation of mood. Con

SUBMITTER: Steinacher A 

PROVIDER: S-EPMC3653950 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature