Inhibition of polyisoprenylated methylated protein methyl esterase by synthetic musks induces cell degeneration.

ABSTRACT: Synthetic fragrances are persistent environmental pollutants that tend to bioaccumulate in animal tissues. They are widely used in personal care products and cleaning agents. Worldwide production of Galaxolide and Tonalide are in excess of 4500 tons annually. Because of their widespread production and use, they have been detected in surface waters and fish in the US and Europe. Consumption of contaminated water and fish from such sources leads to bioaccumulation and eventual toxicity. Since fragrances and flavors bear structural similarities to polyisoprenes, it was of interest to determine whether toxicity by Galaxolide and Tonalide may be linked with polyisoprenylated methylated protein methyl esterase (PMPMEase) inhibition. A concentration-dependent study of PMPMEase inhibition by Galax

SUBMITTER: Ayuk-Takem L 

PROVIDER: S-EPMC3654042 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature